The experimental drug MitoTam, which is the result of research by experts from the Institute of Biotechnology and which has been tested in the IPHYS CAS test facility, shows its potential. In the CPT we tested the safety of MitoTam after intravenous and oral administration to rats and we also…
The Center for Preclinical testing (CPT) won the tender of a foreign sponsor to perform a comprehensive toxicity study in the Good Laboratory Practice (GLP) regime. The study includes 90-day repeated administration of 2 experimental substances with toxicokinetic analysis. Part of the experiment is the evaluation of clinical manifestations of…
A pilot pharmacokinetic study was performed at the IPHYs CAS, which included the determination of the concentration of the experimental drug in the plasma of rats and also in the brain tissue after intraperitoneal administration of the drug. This study required precise brain perfusion of experimental animals and homogenization of…
For our partner from the Czech Academy of Sciences (CAS), we performed a pharmacokinetic study with an experimental drug with antibiotic activity, which included the determination of the pharmacokinetic profile and biodistribution of the drug in plasma and selected matrices after oral administration of the substance to rats. We also…